If the destination is NOT located on the source, this can be the result of a backup job created before rebooting a system after installing ShadowProtect. Re-create the job. If that doesn't work see this KB to del the registry folder "volsettings" under:
HKLM>System>CurrentControlSet>services>ShadowProtectSvc
Then reboot the system or restart the ShadowProtect services.
See KB:
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